Day: March 4, 2023

Antidiabetic Effects of GIP in T2DM and Obesity

In normal humans, glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells, which are located in the proximal duodenum and jejunum. Its concentration rises rapidly following nutrient ingestion, promoting modest inhibitory effects on gastric acid secretion and motility. Its 59 kDa G protein-coupled receptor is found in the beta cells of the pancreas and enables them to detect glucose and release insulin as a result. However, in patients with T2DM a reduction in the insulin response to GIP is observed, even at supraphysiological concentrations, implying that resistance to GIP has developed. The inability of GIP to induce the glucose-induced

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PT 141 Overview

PT 141 Overview The pt 141 peptide, also known as Bremelanotide, is a novel treatment for sexual dysfunction. It has been shown to improve hypoactive sexual desire disorder in women, and erectile dysfunction in men. It activates the MC-4 receptor, which is known to influence sexual behavior and increase sexual arousal in both males and females[1]. The MC4 receptor also plays a key role in stimulating blood flow to the penis to generate an erection. pt 141 is a synthetic, non-selective melanocortin agonist and has shown excellent oral and subcutaneous bioavailability in mice. It is currently being studied in a

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Cerluten Review

Cerluten is a peptide complex that helps maintain and regulate your brain and central nervous system. Its aim is to target and selectively interact with different cells of the nervous system and brain tissues in order to boost the metabolism and enhance the function of these tissues. The main function of the central nervous system is to receive different electrical signals and nerve impulses, send them through the brain to all the body’s cells, coordinate the functions of internal organs, and respond to environmental changes. But sometimes the central nervous system starts malfunctioning and causes various pathological states which lead

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