Drugs That Mimic the Effects of GIP and GLP-1

Glucose-dependent insulinotropic polypeptide (GIP) is a hormone secreted by K cells in the small intestine that enhances the release of insulin following a meal. GIP is a member of a family of hormones called incretins, which interact with hunger hormones to help keep blood sugar levels normal after eating.

Medications that mimic the effects of GIP and GLP-1 are called GIP receptor agonists. Your doctor may prescribe these drugs if you have diabetes or if you are having trouble controlling your blood sugar with other medications.

What are the main differences between GIP receptor agonists and GLP-1 receptor agonists?

One difference is that GIP agonists slow down the stomach’s ability to empty food into your intestine, whereas GLP-1 receptor agonists speed up this process. This can help you lose weight more effectively, especially when they are used together for type 2 diabetes or weight loss.

What are the other differences between GIP receptor agonists and other types of diabetes medications?

Probably the most important difference is that some GIP receptor agonists are used to treat people who have type 2 diabetes. This is because they are believed to work more effectively than other treatments in helping people control their blood sugar and losing weight.

What are the other drugs that mimic the effects of GIP and GLP-1?

Most of these drugs are taken by injection. The two most common injectable GIP receptor agonists are semaglutide (Ozempic) and exenatide (Byetta). Other dual GIP-GLP1 receptor agonists include dulaglutide (Trulicity), liraglutide (Victoza), and ramelteonate (Lantus). They can be used to treat diabetes or to help lose weight. They aren’t often used as first-line treatment for T2D.


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