Gold Peptide – The Next Generation of Anti-Wrinkle Creams

Gold peptide is designed to be the next generation of anti-wrinkle creams. It works by releasing active ingredients in the skin and improving cell turnover, which reduces the appearance of fine lines and wrinkles. The peptide can also be used to treat hyperpigmentation. The product is supplied lyophilized and can be stored at -20i? 1/2C for long time or at -80i? 1/2C for short time. All peptides are QC checked by MALDI-MS and HPLC and the corresponding QC report is provided with each shipment.

The peptide was synthesized using an AAPPTEC 396 omega robotic system (Advanced Chemtech) in the presence of a mixture of thioanisole/anisole/1,2-ethanedithiol (90:5:2:3 v/v/v) and acetonitrile (0.1% TFA). The synthesis was completed in 2 h and the crude peptide was purified by reversed-phase Hitachi HPLC on a 10 mm ODS reversed-phase column (L-2455) using a gradient of 0-100% acetonitrile (0.1% TFA) and cold diethyl ether (Et2O) over 60 min.

Peptide capped gold nanoparticles were characterized by different techniques, including UV-Vis spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS). After photochemical reduction under UV radiation, the peptide hydrogel changed from transparent to purple, indicating the formation of cTnI-AuNPs. The GPNPs are characterized by their size and shape as shown in Figure 2. TEM analysis shows that the peptide capped gold nanoparticles are arranged into self-organized clusters with the average size of GPNPs being around 5.16 nm. Energy-dispersive X-ray spectroscopy (EDS) confirms the presence of gold elements on the surface of GPNPs.


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