Kisspeptin testosterone is a hormone produced by the Hershey chocolate company that can help increase testosterone levels in men. Research shows that low testosterone levels are linked to heart disease, diabetes and other problems in men.
Testosterone is essential for male sexual development and reproductive behaviour. It is a key regulator of the hypothalamic-pituitary-gonadal (HPG) axis and is thought to be involved in the control of various sexual behavioural traits including mating, aggression and territoriality.
The HPG axis is activated through GnRH which acts on the hypothalamus to produce gonadotropin-releasing hormone (GnRH) that then stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH then increases testosterone secretion by stimulation of Leydig cells.
Gonadotropin-releasing hormone and testosterone production are regulated by an interaction between the hypothalamus and pituitary glands that involves a negative feedback loop. When LH pulse frequency decreases due to low GnRH, the testicles will cease producing testosterone.
It is believed that Kisspeptin can counteract this negative feedback loop by stimulating the pituitary gland to release GnRH and causing an increased frequency of GnRH pulse generation, thereby increasing testosterone secretion. This is why it is used as a replacement for human chorionic gonadotropin (hCG) in testosterone replacement therapy programs.
Reproduction is complex and requires intricate synchronisation of multiple neural, endocrine and related behaviours to ensure that mating occurs at the most suitable time in order to maximise survival for the animal. Understanding kisspeptin’s role in the control of this process will help to improve our understanding of sexual biology and develop new therapeutic strategies for the treatment of a wide range of sexual and behavioural disorders.