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Lasso Peptide Engineering

Among natural products, lasso peptides are unique in that they are highly stable and easily engineerable. These features make lasso peptides ideal candidates as molecular scaffolds for the development of therapeutic drugs. Recent advances in genomics, bioinformatics, and chemical analytics have greatly facilitated the discovery of lasso peptides in nature. As the number of lasso peptide biosynthetic gene clusters (BGCs) continues to increase, the need for efficient heterologous expression and structural analysis becomes increasingly pressing. In this context, a promising approach has been to use a combination of site-selective chemical modification of the coding sequences of the BGC and heterologous

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Sermorelin HGH

Sermorelin hgh is a man-made analog of GHRH that stimulates the body to produce natural growth hormone. It is a 29-amino acid fragment that has been proven to bind and stimulate GH secretion by the pituitary gland. It was first approved by the FDA in 1990 to help diagnose GH deficiency. When used correctly, sermorelin therapy can reduce the many symptoms associated with low hgh levels such as fatigue, aging skin signs, loss of muscle mass, weight gain, slower metabolism and more. By restoring healthy levels of hgh, patients often report feeling like a younger version of themselves with increased

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Gold-Peptide Nanoparticles for Viral Diagnosis

The detection of viruses like SARS-CoV-2 and influenza A is a challenge that requires simple and fast diagnostic platforms. To address this issue, we have synthesized a gold-binding peptide that exhibits an antigen affinity for the helix-loop-helix structure of virus nucleic acids [1, 2]. This peptide has been used to form a gold-peptide nanoparticle (GPNP) composite as a promising platform for viral diagnosis. To investigate peptide-gold interactions, we employed a photochemical strategy where the peptide functions as an in situ reducing, capping, and stabilizing agent without the addition of toxic reducing agents. Upon UV exposure, the aromatic residue on the

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Kisspeptin

Kisspeptin, also known as’metastin’, is an incredible complex peptide that has been shown to suppress cancer cell growth and metastasis. It is a pleiotropic protein that acts in many ways, including altering mood and behaviour and modulating hormone signalling during puberty and reproduction. Interestingly, the gene for this peptide has been linked to the melatonin receptor (MTR1). This makes it possible that sleep cycles influence both the levels of melatonin and kisspeptin. In one experiment, mice kept in darkness had low levels of both melatonin and kisspeptin, whilst those exposed to daylight had high levels of each. The mice with

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Antibacterial Peptides

Antibacterial peptides (AMPs) are naturally occurring small protein fragments that can effectively kill microorganisms. They are capable of binding to the negatively charged membranes of bacteria through electrostatic and hydrophobic interactions, thereby disrupting their structure and killing them. The AMPs are generally cationic in nature and have a strong affinity for the negatively charged lipids of bacterial membrane such as cardiolipin, phosphatidylglycerol and sphingomyelin. However, the AMPs do not have significant interaction with the zwitterionic phospholipids found in mammalian cell membranes which are composed of phosphatidylcholine, phosphatidylethanolamine, and huge concentration of cholesterol. This reduces their cytotoxicity towards eukaryotic cells. Depending

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How Peptides Direct Bacterial Membranes

Peptides are amino acid chains that act as a messengers between cells and the body’s systems. They can modulate a wide range of cellular processes including hormones, growth factors and neurotransmitters. They are used in everything from cosmetics to medications to treat conditions like diabetes and multiple sclerosis. Unlike proteins that are long chains of amino acids, peptides have smaller structures and are able to penetrate the intestines, skin and bloodstream more easily. They are also able to reach the target cells in more precise ways than larger proteins. Antimicrobial peptides (AMPs) have garnered increasing attention as a potential alternative

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What Are Peptides?

Peptides are the building blocks of proteins, including collagen, elastin and keratin, which are responsible for the skin’s structure, strength and resilience. They also act as a messenger, triggering cells to perform specific functions, encouraging skin to look and feel younger. There are many naturally-occurring peptides of varying complexity, and a wide range of essential biological functions they fulfil. Generally, they are shorter than proteins (a chain of more than 50 amino acids), and less well-defined in structure, although the N-terminal end of peptides can often form a disulfide bond with cysteines present in adjoining chains, resulting in secondary, tertiary

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Achieve Wellness With Peptide Treatment

If you’re looking to boost your health and achieve ultimate wellness, peptide treatment may be the perfect solution. Peptide therapy involves a series of natural hormones and chemicals that can stimulate your body’s innate healing processes to promote greater health and vitality. Our team at Aether Medicine in Wayne, PA is committed to helping you reach your full potential with our innovative peptide therapy. Unlike proteins, peptides are smaller and easier for the body to absorb. Peptide therapies can also be injected subcutaneously, which allows them to enter the bloodstream quickly and make use of the body’s natural healing capabilities.

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BPC 157 and TB 500 – A Super-Peptide

BPC 157 and tb 500 are two very powerful recovery peptides that work in complementary ways to promote healing. Stacking them together provides an even more potent synergy than either peptide alone. The combination is often referred to as a “super-peptide.” Veterinary professionals have reported that when administered to animals suffering from injury or musculoskeletal problems, it accelerates healing through multiple pathways. Both peptides are made from the amino acid threonine. They are similar in that they both are synthetically created and both mimic the structure of natural body protection compound (BPC). However, tb 500 is much more closely related

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Cerebrolysin and Acute Ischaemic Stroke

Cerebrolysin is a mix of enzymatically treated neuropeptides and amino acids from the brains of pigs. It is widely used in many European and Asian countries as an injection to treat stroke, traumatic brain injury and dementia. However, it is not approved in the US and a recent large study cast doubts on its effectiveness in acute ischaemic stroke. Two multicentre studies compared cerebrolysin with placebo (one from CASTA and one from CERE-LYSE-1 2012). The first trial included participants who had a proximal ischemic stroke. The second included participants who had a non-proximal ischemic stroke or haemorrhage. Both studies administered

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