Thymosin Beta 4
Thymosin beta 4 is a hormone secreted by the Thymus that is important in promoting the production of T cells. T cells are essential for the immune system and help the body fight infection. Thymosin also helps the development of B cells. This hormone belongs to the highly conserved family of actin monomer-sequester proteins. Thymosin beta 4 is available in various forms, including 3,000 mcg/mL subcutaneous injections and 5mL vials.
Thymosin beta 4 is a polypeptide that contains 43 amino acids and is about 5kDa. It is a major mediator of cell proliferation, migration, and differentiation. It is also considered to be an angiogenic protein that helps the body repair trauma. It has been shown to enhance wound healing and reduce inflammation and scarring. Moreover, this polypeptide also helps strengthen muscles and tissues.
The peptide is a promising candidate for cardiac regenerative and cardioprotection research. In preclinical experiments, it improves cell survival after myocardial injury, reduces inflammation, and activates epicardial progenitor cells. The molecule also plays a critical role in cardiac purinergic signaling.
It also promotes wound healing in various tissues, including the eye. The molecule also promotes corneal epithelial cell migration, decreases inflammation, and has anti-apoptotic effects. It also up-regulates the expression of laminin-5, a subepithelial adhesion protein that is present in the basement membrane region of the cornea. Thymosin beta 4 has demonstrated its effectiveness in repairing non-healing corneal ulcers and epithelial wounds in animal models. In addition, it has been shown to be safe in twenty-four nonclinical studies.