Epithalamin is a natural polypeptide found in the pineal gland that regulates melatonin production and circadian rhythm. It has been shown to help improve sleep and boost energy levels. It also helps reduce inflammation, slow cellular aging, and enhance cardiovascular health.
Research in 1998 demonstrated that boosting the activity of telomerase–an enzyme responsible for replicating DNA so that cells can repair damage–extended the lifespan of human somatic (skin) cells in culture. The study also revealed that epithalamin had anti-inflammatory and antioxidant properties, which may play an important role in slowing aging and improving health.
In animal studies, epithalamin was also able to reduce mortality and improve heart disease risk factors in mice. It has been proven to extend the lifespan of mice, fruit flies, and Drosophila melanogaster.
Synthetic peptide preparations containing epithalamin and Epitalon have been shown to restore normalization of night release of endogenous melatonin in both monkeys and people with pineal gland functional insufficiency. They have no side effects and can be used in clinical geriatric practice.
Peptide preparations containing epithalamin and epitalon have been proven to be effective in restoring age-related changes in the function of the pineal gland of rhesus monkeys. They have been shown to restore night and average daily levels of melatonin in the blood plasma, normalize hormone circadian rhythm amplitude, and reduce the severity of aging-related changes in the metabolism.
The peptide-treated patients had a 2.0-2.4-fold decrease in acute respiratory disease incidence, ischemic heart disease clinical manifestations, hypertension, deforming osteoarthrosis, and osteoporosis as compared to the control group. The restoration of homeostasis in the peptide-treated patients also corresponded to a decrease in mortality rate.